课程名称︰分析化学丁
课程性质︰药学系 医学检验暨生物技术学系 必修
课程教师︰张焕宗
开课学院：理学院
开课系所︰化学系
考试日期（年月日）︰March 26, 2014
考试时限（分钟）： 180分钟
是否需发放奖励金： 是
（如未明确表示，则不予发放）
试题 :
I. Comparison: (21 pts, 3 pts each)
(II) Buffer (9pts, 3 pts each):
(III) Acid and base: (15 pts; 6 pts for (1), 3 pts each for the rest)
(IV) Solubility (6 pts, 3 pts each)
(V) Absorption (21 pts, 3 pts each)
(VI) Calculation (9 pts, 3 pts each)
(VII) Standard addition method (9 pts, 3 pts each)
(VIII) Methodology (9 pts, 3 pts each)
(IX) Drug analysis (12 pts; 6 pts for (2), 3 pts for the rest)
Atorvastatin calcium (ATR) is mainly used for lowering blood cholesterol, while
ezetimibe (EZ) is used for the treatment of hypercholesterolemia and homozygous
sitosterolemia. Combination of ATR and EZ has the advantages of greater
therapeutic effects than with either drug alone. This combination causes
manifold reduction in LDL cholesterol level as compared to double dose of the
individual drug when used alone. Moreover, using of EZ with ATR enhances the
effects of statins at lower dose and reduces the associated side effects. The
UV-vis spectra for ATR (solid curve) and EZ (dotted curve) are shown below.
(1) Why is it advantageous of using a cmobination of the two drugs over
individual?
(2) Suggest a spectrometric method for the determination of the contents of the
two drugs in a pure mixture containing the two drugs.
(3) Is sample pretreatment necessary for the determination of the
concentrations of the two drugs in blood samples prior to the spectrometric
analysis? Why?