中文文字部分来自 以色列经济贸易办事处
http://itrade.gov.il/taiwan/?p=4332 文字内容出处
八仙尘爆后，许多人因此而留下无法抹灭的痕迹，虽然存活了下来，但这些永久存在的疤
痕也许会造成生理、心理甚至是社交上的压力。以色列特拉维夫大学以及美国哈佛大学的
顶尖研究员共同致力于烧烫伤复原的领域，发展了一项不需要额外手术的方式让伤口自然
的复原，并不留下疤痕的技术。
遭受烧烫伤后，过多的胶原蛋白的产生是导致疤痕留下的原因。而研究团队所发展的特殊
技术partial irreversible electroporation (pIRE)，是能够防止烧烫伤疤痕形成的关
键。在一连串的老鼠实验后，与未治疗的对照组相比，经过六个月治疗的疤痕区域很明显
有57.9%的减少，研究团队也正努力找出治疗技术的平衡点，避免过度治疗或是形成新的
伤口。现在，他们找到了开关，而下一步，将会是募资并执行进一步的人体临床试验，相
信未来此技术将会在医界里注入新的能量。
英文资料出处 http://goo.gl/HKP9Qu AUGUST 15, 2016, 8:20 AM
相关资料下载 http://goo.gl/gI1SMf
Novel non-invasive technology may prevent burn scars
Israeli and American researchers develop method to control collagen-cell
proliferation that produces scarring.
A group of researchers from Tel Aviv University and Harvard University is
proposing a new non-invasive method to prevent burn-related hypertrophic
scars — raised tissue caused by excessive collagen — using short, pulsed
electric fields.
“People don’t die from scars, but they do suffer from them,” said Dr.
Alexander Golberg of TAU’s Porter School of Environmental Studies. “We
believe that the technology we developed, called partial irreversible
electroporation (pIRE), can be used to prevent debilitating burn scars from
forming.”
According to the World Health Organization, 10 percent of all
unintentional-injury deaths result from burns. But even for those who survive
the destruction of skin and tissue cells, post-burn scarring creates lifelong
physical, psychological and social suffering.
The experimental pIRE technique harnesses microsecond-pulsed, high-voltage,
non-thermal electric fields to control the body’s natural response to trauma
— the proliferation of collagen cells that cause permanent scarring at the
site of injury.
The technique was applied to burn injuries in rats during five therapy
sessions over the course of six months. Using an imaging technique developed
at the Wellman Center of Photomedicine at Massachusetts General Hospital, the
researchers assessed the treated wounds and found a 57.9% reduction of the
scar area in comparison with untreated scars.
The researchers tried to find a delicate balance so that the technique didn’
t create a new wound or “overheal” the existing wound, because scarring is
the body’s natural way of healing.
The study, supported by the Shriners Foundation, was led by Golberg together
with Dr. Martin Yarmush of the Center for Engineering in Medicine at
Massachusetts General Hospital, Harvard Medical School and Shriners Burns
Hospital in Boston.
Researchers from Harvard-affiliated institutions and from the department of
biomedical engineering at the University of Arkansas also participated.
Their results recently were published in the Journal of Investigative
Dermatology. The authors caution that the findings were limited by the fact
that rats do not develop hypertrophic scars and therefore human trials are
essential.
“Scarring is a very complex process, involving inflammation and metabolism,
” said Golberg. “We have found a way to partially prevent scar formation in
animal models. Next we need to raise funding to develop a device for the
clinical study on humans.”
Surgical excision, laser therapy, electron-beam irradiation, mechanical
compression dressing, silicone sheet application and other techniques have
been tested to treat scars over the years, said Golberg. “But there have
been only modest improvements in the healing outcomes among all these
treatments.”