Abstract for Reference 36: Treatment of androgenetic alopecia in men36TIEffects of finasteride (1 mg) on hair transplant.AULeavitt M, Perez-Meza D, Rao NA, Barusco M, KaufmanKD, Ziering CSODermatol Surg. 2005 Oct;31(10):1268-76, discussion1276.BACKGROUND: The improved scalp coverage achieved byhair transplant for men with androgenetic alopeciacan be diminished by continued miniaturization andloss of preexisting, nontransplanted hairs.OBJECTIVES: To evaluate whether finasteride 1 mg, administered daily from 4 weeks before until 48 weeks after hair transplant, improves scalp hair and growth of nontransplanted hair in areas surrounding the transplant and to evaluate the safety and tolerability of finasteride for men undergoing hair transplant.METHODS: In this randomized, double-blind, placebo-controlled study, 79 men with androgenetic alopecia(20-45 years of age) were assigned to treatment with finasteride 1 mg (n = 40) or placebo (n = 39) once daily from 4 weeks before until 48 weeks after hair transplant. Efficacy was evaluated by review ofglobal photographs by an expert dermatologist andby macrophotography for scalp hair counts.RESULTS: Treatment with finasteride resulted in significant improvements from baseline,compared with placebo, in scalp hair based on global photographicassessment (p<.01) and hair counts (p<.01) at week48. Visible increases in superior/frontal scalp hair post-transplant were recorded for 94% and 67% ofpatients in the finasteride and placebo groups, respectively. Finasteride treatment was generally well tolerated.CONCLUSION: For men with androgenetic alopecia, therapy with finasteride 1 mg daily from 4 weeks before until 48 weeks after hair transplant improves scalp hair surrounding the hair transplant and increases hair density.ADMedical Hair Restoration, 120 International Parkway, Ste. 240, Heathrow, FL 32746, USA.
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