课程名称︰分子生物学
课程性质︰必修
课程教师︰王爱玉/黄枫婷
开课学院：生命科学院
开课系所︰生化科技学系
考试日期（年月日）︰2016/11/07
考试时限（分钟）：120分钟
试题 :
（以下为本学期第二次期中考，由王爱玉老师与黄枫婷老师共同出题）
爱玉老师部分：占50%
（事先公布试题，考试当天不得带大抄）
有些疾病已知与DNA repair system无法正常运作有关。
请搜寻文献，找出任五种与DNA repair缺失相关的疾病。
每种疾病10分，每一种疾病皆需叙述：
1) 此疾病的名称及主要特征 （2分）
2) 是导因于哪一种（或哪些）DNA repair system 发生问题？（写出名称即可）（2分）
3) 此 DNA repair system 正常机制为何？造成疾病的关键点为何？（6分）
枫婷老师部分：占51%
1. In cells, what will be the effect if meiotic recombination does not occur?
(3%)
2. Please describe the six biological functions of homologous recombination.
(6%)
3. Please describe the differences between HR and CSSR. (Hint: Where? How?)
(6%)
4. Please describe and draw the three different types of site-specific
recombination. (6%)
5. Gene conversion usually occurs in different organisms with different
mechanisms. Please describe two types of gene conversion in detail.
(Hint: in HR and CSSR) (8%)
6. Transposition is carefully regulated in organisms to protect the chromosome
integrity. Please describe two types of mechanisms that transposition is
regulated, each with an example to illustrate in detail. (10%)
7. Please describe each step of the homologous recombination and write down
the proteins mainly responsible for each step in RecBCD pathway. (12%)