(图多, 可以点下方的ptt连结看全部的图片喔! 不用一张一张点开)
http://on.fb.me/1pGAL2L 转自 PanSci 科学新闻网
Written By: 阿贼
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抗组织胺的药物会因病情的不同，其药物也有好几种，因为光是组织胺的接受器目前为止
就发现4型，也有作用在影响组织胺生合成的部分。
现在的医生也会依照病人的需求开给他2或3代的抗组织药物，比起第一代嗜睡的情况已经
改善很多，但是有些paper也指出2,3代的药物还是有一定得机率通过血脑屏障影响中枢神
经，过多的剂量也是会有嗜睡的风险，建议吃药时还是不要从事需要高度专注的工作喔!
如果对我的内容有意见的或是要补充点资料欢迎跟我讨论啊！！！
备注：
拮抗剂(antagonist)指某一类物质会与其受体(或接受器)结合，但不具备活化其受体功能
血脑屏障(blood–brain barrier (BBB)，指在生物体内脑袋与血管之间由内皮细胞（
endothelial cells）排列而成，其细胞之间有着间隙选择性地或是阻止某些物质由血进
入脑
资料来源：
Saper C.B., Chou T.C., et al. (2001).” The sleep switch: hypothalamic
control of sleep and wakefulness.” Trends Neurosci. 24(12):726-31.
del Cuvillo A, Mullol J., et al. (2006).” Comparative pharmacology of the H1
antihistamines.” J Investig Allergol Clin Immunol. 16 Suppl 1:3-12.
Benarroch E.E. (2010).” Histamine in the CNS: multiple functions and
potential neurologic implications.” Neurology. 75(16):1472-9
Ramaekers J.G. and Vermeeren A. (2000). ” All antihistamines cross
blood-brain barrier.” BMJ. 321(7260):572.
Zeitzer J.M. (2013). “Control of sleep and wakefulness in health and disease.
” Prog Mol Biol Transl Sci. 119:137-54
Walsh G.M., Annunziato L., et al. (2001). “New insights into the second
generation antihistamines.” Drugs. 61(2):207-36.
Criado P.R., Criado R.F., et al. (2010). “Histamine, histamine receptors and
antihistamines: new concepts.” An Bras Dermatol. 85(2):195-210.
Pardridge W.M. (2005). “The blood-brain barrier: bottleneck in brain drug
development.” NeuroRx. 2(1):3-14.
Haas H. and Panula P. (2003). “The role of histamine and the tuberomamillary
nucleus in the nervous system.” Nat Rev Neurosci. 4(2):121-30.
Thurmond R.L., Gelfand E.W., et al. (2008). “
The role of histamine H1 and H4 receptors in allergic inflammation: the
search for new antihistamines.” Nat Rev Drug Discov. 7(1):41-53
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心得: 这漫画画的好生动 >///<b