[心得] 高端一期试验与AZ疫苗二期试验抗体比较

楼主: richard85 (@.@)   2021-06-10 15:09:21
高端一期临床试验
After the second vaccination, the SARS-CoV-2 spike specific IgG
titers increased with peak geometric mean titers at 7178.245 (LD), 7746.086
(MD), and 11220.58 (HD), respectively.
论文出处: https://www.medrxiv.org/content/10.1101/2021.03.31.21254668v1
AZ二期临床试验
In participants who received two doses of vaccine, median anti-spike
SARS-CoV-2 IgG responses 28 days after the boost dose were similar across the three age cohorts
(standard-dose groups: 18–55 years, 20713 arbitrary units [AU]/mL [IQR 13898
–33550], n=39; 56–69 years, 16170 AU/mL [10233–40353], n=26; and >70 years 17561 AU/mL [9705–37796], n=47; p=0.68)
论文出处:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32466-1
结论:
从高端一期报告来看
高端抗体效价要赢过AZ应该不容易
但两者试验族群不同(东方VS西方国家)
所以还是要以AZ近来台湾施打后的抗体报告为准
作者: observer0117 (ob)   2021-06-10 15:37:00
这些都是随意单位无法比较只看数字是没有意义的,AU只能自己和自己比arbitrary就是随意的,自订的单位,高端的定义和AZ的定义不太可能相同,实验方法设备也不太可能相同台湾的200人也许可以比,但这200人是台大做的,是否和高端临床试验中使用的分析方法一样也很难说

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