※ [本文转录自 Gossiping 看板 #1KCrYCO5 ]
作者: WalterbyJeff (Hun Rhapsody) 看板: Gossiping
标题: [新闻] 实验室培养的阴茎准备用于人身上
时间: Tue Oct 7 11:05:45 2014
1.媒体来源:
2.完整新闻标题/内文:
Scientists ready to test lab-grown penises on men
Penises grown in laboratories could soon be tested on men by scientists deve-
loping technology to help people with congenital abnormalities, or who have
undergone surgery for aggressive cancer or suffered traumatic injury.
实验室培养的阴茎可望近期内在人体测试，以此帮助先先天性畸形、经历过癌症治疗手术
或承受过外伤的人。
Researchers at the Wake Forest Institute for Regenerative Medicine in Winston-
Salem, North Carolina, are assessing engineered penises for safety, function
and durability. They hope to receive approval from the US Food and Drug Admini-
stration and to move to human testing within five years.
研究人员在伟克森林研究院对于再生医疗，正在评估兼具安全、功能跟耐受性的人工阴茎
。他们希望在五年内获得美国食品药物局的核准进入人体测试阶段。
Professor Anthony Atala, director of the institute, oversaw the team's success-
ful engineering of penises for rabbits in 2008. "The rabbit studies were very
encouraging," he said, "but to get approval for humans we need all the safety
and quality assurance data, we need to show that the materials aren't toxic,
and we have to spell out the manufacturing process, step by step."
研究单位主持人，安森尼艾塔拉教授，监督整个研究团队于2008年在测试人工阴茎于
兔子上的成功。"兔子的研究让人非常鼓舞"他说，"但是要能获准人体测试，我们需要
资料能确保安全与品质，我们需要展现这些材料并无毒性，并且我们需要一步一步说明
整个制作过程。"
The penises would be grown using a patient's own cells to avoid the high risk
of immunological rejection after organ transplantation from another individual.
Cells taken from the remainder of the patient's penis would be grown in
culture for four to six weeks.
这些阴茎会使用病患本身的细胞来培养以避免从另外一个人身上移植之后，产生免疫排斥
的高风险。
For the structure, they wash a donor penis in a mild detergent to remove all donor cells. After two weeks a collagen scaffold of the penis is left, on to which they seed the patient's cultured cells – smooth muscle cells first, then endothelial cells, which line the blood vessels. Because the method uses a patient's own penis-specific cells, the technology will not be suitable for female-to-male sex reassignment surgery.
"Our target is to get the organs into patients with injuries or congenital abnormalities," said Atala, whose work is funded by the US Armed Forces Institute of Regenerative Medicine, which hopes to use the technology to help soldiers who sustain battlefield injuries.
As a paediatric urological surgeon, Atala began his work in 1992 to help children born with genital abnormalities. Because of a lack of available tissue for reconstructive surgery, baby boys with ambiguous genitalia are often given a sex-change at birth, leading to much psychological anguish in later life. "Imagine being genetically male but living as a woman," he said. "It's a firmly devastating problem that we hope to help with."
Asif Muneer, a consultant urological surgeon and andrologist at University College hospital, London, said the technology, if successful, would offer a huge advance over current treatment strategies for men with penile cancer and traumatic injuries. At present, men can have a penis reconstructed using a flap from their forearm or thigh, with a penile prosthetic implanted to simulate an erection.
"My concern is that they might struggle to recreate a natural erection," he said. "Erectile function is a coordinated neurophysiological process starting in the brain, so I wonder if they can reproduce that function or whether this is just an aesthetic improvement. That will be their challenge."
Atala's team are working on 30 different types of tissues and organs, including the kidney and heart. They bioengineered and transplanted the first human bladder in 1999, the first urethra in 2004 and the first vagina in 2005.
Professor James Yoo, a collaborator of Atala's at Wake Forest Institute, is working on bioengineering and replacing parts of the penis to help treat erectile dysfunction. His focus is on the spongy erectile tissue that fills with blood during an erection, causing the penis to lengthen and stiffen. Disorders such as high blood pressure and diabetes can damage this tissue, and the resulting scar tissue is less elastic, meaning the penis cannot fill fully with blood.
"If we can engineer and replace this tissue, these men can have erections
again," said Yoo, acknowledging the many difficulties. "As a scientist and
clinician, it's this possibility of pushing forward current treatment
practice that really keeps you awake at night."
“如果我们能够取代这些组织，这些男性将能够再度勃起。”游说，承认这当中有许多
困“作为一个科学家跟医生，这种能够将现行的治疗方式往前推进的可能性，真是的能够
让人晚上不眠。”
3.新闻连结:
http://www.theguardian.com/science/2014/oct/05/laboratory-penises-test-on-men
4.备注:
之前阴茎被太太剪断冲掉的人有救了!!!