嘘 NEWinx: 英国研究 10/31 09:11
http://www.ncbi.nlm.nih.gov/pubmed/21666693
Variation in genome-wide mutation rates within and between human families.
Nat Genet. 2011
推 Pietro: 这个叙述太简略了 难怪会有人看一下就呛英国研究 10/31 09:20
的确是太简单了，而且原文其实也没提到60这数字，我觉得60是记者为了方便从原文推
算出来的数字吧！
原本的paper其实就只是打算估算一个人身上会出现多少不是由父母亲传来的突变而已。
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322360/pdf/ukmss-36509.pdf
Abstract
J.B.S. Haldane proposed in 1947 that the male germline may be more mutagenic
than the female.Diverse studies have supported Haldane’s contention of a
higher average mutation rate in the male germline in a variety of mammals,
including humans. Here we present the first direct comparative analysis of
male and female germline mutation rates from complete genome sequences of two
parent-offspring trios. Through extensive validation, we identified 49 and 35
germline de novo mutations (DNMs) in two trio offspring, as well as 1,586
non-germline DNMs arising either somatically or in the cell-lines from which
DNA was derived. Most strikingly, in one family we observed that 92% of
germline DNMs were from the paternal germline, while, in complete contrast,
in the other family 64% of DNMs were from the maternal germline. These
observations reveal considerable variation in mutation rates within and
between families.