美国国家科学院学报 (Early Edition) 出版前预览的最新文章
http://www.pnas.org/content/early/2014/07/17/1405186111
RNA-directed gene editing specifically eradicates latent and prevents new
HIV-1 infection
For more than three decades since the discovery of HIV-1, AIDS remains a
major public health problem affecting greater than 35.3 million people
worldwide. Current antiretroviral therapy has failed to eradicate HIV-1,
partly due to the persistence of viral reservoirs. RNA-guided HIV-1 genome
cleavage by the Cas9 technology has shown promising efficacy in disrupting
the HIV-1 genome in latently infected cells, suppressing viral gene
expression and replication, and immunizing uninfected cells against HIV-1
infection. These properties may provide a viable path toward a permanent cure
for AIDS, and provide a means to vaccinate against other pathogenic viruses.
Given the ease and rapidity of Cas9/guide RNA development, personalized
therapies for individual patients with HIV-1 variants can be developed
instantly.
简单来说，就是透过一种可以切 DNA 的蛋白质，把 HIV 基因从被感染的细胞，
例如微胶细胞 (microglia) 及 T 细胞 (T Cell) 切除，并能因此避免新 HIV 感染。
不过目前看来困难在怎么在人体切到那些被感染的细胞，然后不会切错 XD...