发稿单位：NIH
发稿时间：2021 Apr 20.
撰 稿 者：Raymond Chee Seong Seet etc.
原文连结：https://pubmed.ncbi.nlm.nih.gov/33864917/
Positive impact of oral hydroxychloroquine and povidone-iodine throat spray
for COVID-19 prophylaxis: An open-label randomized trial
Abstract
Background: We examined whether existing licensed pharmacotherapies could
reduce the spread of coronavirus disease 2019 (COVID-19).
Methods: An open-label parallel randomized controlled trial was performed
among healthy migrant workers quarantined in a large multi-storey dormitory
in Singapore. Forty clusters (each defined as individual floors of the
dormitory) were randomly assigned to receive a 42-day prophylaxis regimen of
either oral hydroxychloroquine (400 mg once, followed by 200 mg/day), oral
ivermectin (12 mg once), povidone-iodine throat spray (3 times/day, 270 μ
g/day), oral zinc (80 mg/day)/vitamin C (500 mg/day) combination, or oral
vitamin C, 500 mg/day. The primary outcome was laboratory evidence of
SARS-CoV-2 infection as shown by either: (1) a positive serologic test for
SARS-CoV-2 antibody on day 42, or (2) a positive PCR test for SARS-CoV-2 at
any time between baseline and day 42.
Results: A total of 3037 asymptomatic participants (mean age, 33.0 years; all
men) who were seronegative to SARS-CoV-2 at baseline were included in the
primary analysis. Follow-up was nearly complete (99.6%). Compared with
vitamin C, significant absolute risk reductions (%, 98.75% confidence
interval) were observed for oral hydroxychloroquine (21%, 2-42%) and
povidone-iodine throat spray (24%, 7-39%). No statistically significant
differences were observed with oral zinc/vitamin C combination (23%, -5 to
+41%) and ivermectin (5%, -10 to +22%). Interruptions due to side effects
were highest among participants who received zinc/vitamin C combination
(6.9%), followed by vitamin C (4.7%), povidone-iodine (2.0%), and
hydroxychloroquine (0.7%).
Conclusions: Chemoprophylaxis with either oral hydroxychloroquine or
povidone-iodine throat spray was superior to oral vitamin C in reducing
SARS-CoV-2 infection in young and healthy men.
我直接讲结论,
HCQ 确实可以有效预防武汉肺炎,
效果比 vitamin C 好.
感想:
这篇文章我有先问 swattw 大,
他说不能用新闻发用整理发,
因为我要发之前我考虑到他已经过期,
不符合板规,
所以我才问 swattw 大,
既然他说用整理发,
那我就用整理发.