※ 引述《phosita (phosita)》之铭言：
: ASCO可不是个随随便便的单位，
: 如果实验结果没有显著的意义，
: 要登上ASCO可说是不可能的。
: 如果ASCO接受论文，那不就代表皓鼎的实验有显著的意义？
说到这个倒是想起一个8年前发生的事件,
故事也涉及收购optimer的merck药厂
Drugmakers accused of delaying ENHANCE data
http://tinyurl.com/hj2urvv
http://www.thepharmaletter.com/article/drugmakers-accused-of-delaying-enhance-data
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In the days after results from the ENHANCE study were announced
the share price of both companies suffered. On January 17, shares
in S-P fell 8% and were 22% down over the course of the week. Shares
in Merck dropped 6% on the same day and 9% over the week but the firm
has other big earners in its portfolio and is less exposed, while
Vytorin is S-P's lead drug.
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ENHANCE study是一个降胆固醇药物的研究, April 2006就已完成
放到2008年1月才发布结果,当周S-P股价跌了22%, merck也跌了9%
该研究的论文最后于2008年4月刊登在内科顶尖期刊的NEJM
Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia
http://www.nejm.org/doi/full/10.1056/NEJMoa0800742
N Engl J Med 2008; 358:1431-1443 April 3, 2008
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Conclusions
In patients with familial hypercholesterolemia, combined therapy
with ezetimibe and simvastatin did not result in a significant
difference in changes in intima–media thickness, as compared
with simvastatin alone, despite decreases in levels of LDL cholesterol
and C-reactive protein. (ClinicalTrials.gov number, NCT00552097.)
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请问这算是NEJM给他平反吗? XDD