论文在此
是preprint
https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1.full.pdf
标题
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1
Omicron
节录一下重点
We generated chimeric recombinant SARS-CoV-2
encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2
isolate and compared this virus with the naturally circulating Omicron variant.
The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity,
mainly due to mutations in the receptor binding motif (RBM), yet unlike
naturally occurring Omicron, efficiently replicates in cell lines and
primary-like distal lung cells. In K18-hACE2 mice, while Omicron
causes mild, non-fatal infection, the Omicron S-carrying virus inflicts
severe disease with a mortality rate of 80%.
This indicates that while the vaccine escape of Omicron is
defined by mutations in S, major determinants of viral pathogenicity
reside outside of S.
翻译没有钱拿
阿伯我懒得翻译了
大家自己去用google翻译吧