※ 引述《endoutx (疯骚大叔)》之铭言：
: 先说我不是来替废物政府找借口开脱的。
: 本肥是想问辉瑞口服药是不是又来骗钱的？一个特效药轻症吃可以89%防重症及死亡，听起
: 来很屌，但实际上没吃药轻症率是99.76%，也就是只有0.24%会进到中重症（不排除未来会
: 飙高），那么口服药89%是防三小的？0.24%里的89%？药也贵森森的，为了救0.24%的89%要
: 给100%的人喂药？你说是不是很骗钱？
: 再说口服药限制一堆也很谜，本肥如果说能开发一种奇蹟口服药能防99.9%重症死亡你信吗
: ？只要在药里掺点各种慢性病吃了会母汤的成分，就能排除一堆本来就有病的老人了，其他
: 人吃了就算没效用也不会重症，这样是不是很贼？
: 总之我们废物政府没超前部署买到口服药，说不定不是坏事，至少帮你省很多税金，你看美
: 国确诊就给药还不是死一堆？大家觉得如何？
这个欧美已经有资料啦~
欧盟 (European Medicines Agency) 官网：
https://www.ema.europa.eu/en/medicines/human/EPAR/paxlovid
里面What benefits of Paxlovid have been shown in studies?
A main study involving patients with COVID-19 and at least one underlying
condition putting them at risk of severe COVID-19 looked at the effects of
Paxlovid on rate of hospitalisation or death within 28 days of treatment
when compared with placebo (a dummy treatment). The analysis was done in
patients who received Paxlovid within 5 days after COVID-19 symptoms began
and who did not receive nor were expected to receive treatment with
antibodies. Over the month following treatment, the rate of hospitalisation
or death was 0.8% (8 out of 1,039) for patients who received Paxlovid,
compared with 6.3% (66 out of 1,046) for those who received placebo. There
were no deaths in the Paxlovid group and 12 deaths in the placebo group.
The majority of patients in the study were infected with the Delta variant.
Based on laboratory studies, Paxlovid is also expected to be active against
Omicron and other variants.
简单翻译重点：
针对有风险族群，在症状发生五天内给药，治疗组1039人内有8人住院或死亡 (0.8%)
对照组(给安慰剂)1046人中有66人住院或死亡(6.3%)
在治疗组中没有病人死亡，而在对照组中有12人死亡
以上研究是针对delta变种，但也预期对omicron与其他变种有效
再补充一个研究 (NEJM) Nirmatrelvir是PaxLovid的成份之一
https://www.nejm.org/doi/full/10.1056/NEJMoa2118542
在最后分析
nirmatrelvir plus ritonavira (Paxlovid主成份)治疗组
697人有5人住院(0.72%)、0人死亡(0%)
对照组682组中有44人住院 (6.45%)、9人死亡(1.32%)
结论：
Treatment of symptomatic Covid-19 with nirmatrelvir plus ritonavir
resulted in a risk of progression to severe Covid-19 that was 89%
lower than the risk with placebo, without evident safety concerns.
Paxlovid 当然不是神药，也不是得病就非吃不可，
但当这些高风险病人一旦确诊后，让病人能选择要不要接受药物治疗，不好吗?
当然也可以批评omicron的轻症多，或药物研究是用delta做的~ 但疫苗也是一样啊?
虽然轻症多，现在指挥中心也是大力推行疫苗接种，而这些疫苗开发时delta还没问世呢