[爆卦] ivermectin 的机转研究上了nature的子期

楼主: MPDK (山猪MP)   2021-06-19 00:21:48
https://www.nature.com/articles/s41429-021-00430-5
原文如上,小弟高一之后就没在读生物了,不过英文还是看得懂
就introduction 内容看来,这个药感觉可以寄与厚望(如果我读错了欢迎打脸我),也开?
至于里面内容到底是什么,有没有回答了是不是真的有证实在机转上,此药可行,我就看不
稍微翻译一下我看到觉得让人兴奋的一段好了,完全不负责任翻译。
Several doctor-initiated clinical trial protocols that aimed to evaluate outcomes, such as reduction in mortality figures, shortened length of intensive care unit stay and/or hospital stay and elimination of the virus with ivermectin use have been registered at the US ClinicalTrials.gov [7].
已经有几个临床实验正式申请,且在进行中,想知道此药可不可以降低死亡率,待在医院时间,或是消灭病毒。
Real-time data is also available with a meta-analysis of 55 studies to date.
其中有55个有即时资料
As per data available on 16 May 2021, 100% of 36 early treatment and prophylaxis studies report positive effects (96% of all 55 studies).
早期投药以及预防有正面效果
Of these, 26 studies show statistically significant improvements in isolation.
其中有26个有非常显著的正面效果
Random effects meta-analysis with pooled effects using the most serious outcome reported 79% and 85% improvement for early treatment and prophylaxis respectively (RR 0.21 [0.11–0.37] and 0.15 [0.09–0.25]).
随机性分析有正面效果
The results were similar after exclusion based sensitivity analysis: 81% and 87% (RR 0.19 [0.14–0.26] and 0.13 [0.07–0.25]), and after restriction to 29 peer-reviewed studies: 82% and 88% (RR 0.18 [0.11–0.31] and 0.12 [0.05–0.30]).
即使拿到比较不严谨的实验 也有很好的结果
Statistically significant improvements were seen for mortality, ventilation, hospitalization, cases, and viral clearance. 100% of the 17 Randomized Controlled Trials (RCTs) for early treatment and prophylaxis report positive effects, with an estimated improvement of 73% and 83% respectively (RR 0.27 [0.18–0.41] and 0.17 [0.05–0.61]), and 93% of all 28 RCTs.
所谓三期随机实验也有很好的效果
These studies are tabulated in Table 1. The probability that an ineffective treatment generated results as positive for the 55 studies to date is estimated to be 1 in 23 trillion (p = 0.000000000000043). The consistency of positive results across a wide variety of cases has been remarkable. It is extremely unlikely that the observed results could have occurred by chance [8].
而且看起来不像是运气好的结果
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